Anticancer effect of curcumin drug towards submaxillary gland cell line along with injectable gel : Anticancer effect of curcumin drug towards submaxillary gland cell line along with injectable gel
- 주제(키워드) biotechnology
- 발행기관 아주대학교
- 지도교수 Professor Moon Suk Kim
- 발행년도 2015
- 제출일 2014
- 학위수여년월 2015. 2
- 학위명 석사
- 학과 일반대학원 분자과학기술학과
- 실제URI http://www.dcollection.net/handler/ajou/000000019465
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Use of chemotherapeutic drug against cancer disease is increasing nowadays. In this work we employed natural polyphenol drug curcumin as a chemotherapeutic drug towards sub-maxillary carcinoma cell (A-253). Injectable hydrogel systems had drawn increasing observance for the capable use in a broad range of biomedical applications. Curcumin is hydrophobic in nature with multifunctional characteristics like anti-inflammatory, anti-cancer and increase immune system; however the relative bioavailability of curcumin is major matter. To minimize the stability problem curcumin loaded PLGA microcapsule having 40-45 µM was prepared using mono nozzle ultrasonic atomizer. For effective release of curcumin from curcumin loaded microcapsule 5% tween solution was used which showed 35% release rate within 20 days. Similarly, in vivo histological analysis and apoptosis staining process exhibited that curcumin drug along with natural hydrogel has significant suppressive action against head and neck cancer cell line. Finally, from the results controlled and effective release of curcumin drug from curcumin loaded microcapsule and natural hydrogel consist of tumor inhibition activity within a desired time without any side effect and toxicity.
more목차
List of figures i
List of tablesv
1. Introduction4
2. Experimental10
3. Results23
4. Discussion25
5. Conclusion26
6. Reference32
