European Working Group on Sarcopenia in Older People guideline 에 근거한 혈중 인슐린양 성장인자-1과 근육량, 근력, 신체수행능력과의 상관관계
Association between insulin like growth factor-1 and muscle mass, muscle strength and physical performance based on European Working Group on Sarcopenia in Older People guideline
- 주제(키워드) Insulin like growth factor-1 (IGF-1) , Muscle mass , Muscle strength , Physical performance , Sarcopenia.
- 발행기관 아주대학교
- 지도교수 김광민
- 발행년도 2014
- 학위수여년월 2014. 2
- 학위명 석사
- 학과 및 전공 일반대학원 의학과
- 실제URI http://www.dcollection.net/handler/ajou/000000016237
- 본문언어 영어
- 저작권 아주대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Background : Aging is associated with various changes in body composition, such as a decrease in muscle mass, bone mineral density, and an increase in body fat. We assumed that these changes were accompanied by decrease of IGF-1 level. We aimed to define relationship between IGF-1 level and muscle mass, muscle strength and physical function of the middle aged people and the elderly. Method : In the cross-sectional study, subjects were included who had medical examination in the Ajou University health promotion center. Serum IGF-1 level was measured, and muscle mass was calculated by dual-energy X-ray absorptiometry (DXA). Muscle strength was measured by hand grip strength test and physical performance was tested by 2-m walking test. Results : Mean IGF-1 level was 191.1 ± 50.8 ng /ml in men and was 168.3 ± 49.0 ng /ml in women respectively. Serum IGF-1 level was associated with muscle mass in both genders. Muscle strength and physical performance were positively associated with IGF-1 in women. We also investigated prevalence of sarcopenia based on the definition of European Working Group on Sarcopenia in Older People (EGWSOP) guideline. The prevalence of sarcopenia was associated with low serum IGF-1 level in women. Conclusion : We observed IGF-I was associated with muscle mass in both genders and it was related with muscle strength and physical performance in women. In addition, prevalecnce of sarcopenia was associated with low serum IGF-1 level.
more목차
TABLE OF CONTENTS
ABSTRACT .......................................................................................................................... ⅰ
TABLE OF CONTENTS ........................................................................................................ii
LIST OF FIGURES ................................................................................................................iii
LIST OF TABLES ................................................................................................................. iv
I. INTRODUCTION ................................................................................................................1
II. MATERIALS AND METHODS .........................................................................................3
A. Study Subjects ...................................................................................................................3
B. Body composition and blood test ……..............................................................................3
C. Muscle mass, muscle strength, physical performance ...………………………………....3
D. Definition of sarcopenia ………………………………………………………................4
E. Statistical analysis ………………………………………………………………………. 5
III. RESULTS............................................................................................................................6
A. Baseline characteristics ………………………………………………………………….6
B. IGF-1 level and muscle mass, muscle strength and physical performance………………7
C. Sarcopenia………………………………………………………………………………..8
D. Sarcopenia and IGF-1 level…………………………………………………………… .11
IV. DISCUSSION....................................................................................................................14
V. CONCLUSION...................................................................................................................17
REFERENCES .......................................................................................................................18
국문요약 ...............................................................................................................................21
Fig. 1. Serum IGF-1 level in different age groups .................................................................. 7
Fig. 2. Prevalence of sarcopenia .............................................................................................. 9
Table 1. General characteristics of participants ....................................................................... 6
Table 2. Correlation serum IGF-1 and muscle mass, muscle strength, physical performance and age ..................................................................................................................... 8
Table 3. Odds ratio of sarcopenia components according to IGF-1 quartile ......................... 12
Table 4. Odds ratio of sarcopenia prevalence according to IGF-1 quartile ........................... 13
