라미부딘 내성 만성 B형 간염 환자에 있어 라미부딘과 아데포비어 병용 요법의 치료 효과와 특성 분석
Analysis of Treatment Effect of Lamivudine, Adefovir Add-on Therapy in Patients with Lamivudine Resistant Chronic B-viral Hepatitis
초록/요약
Background: Add on adefovir (ADV) to ongoing lamivudine (LAM) is an established treatment modality for treatment of LAM resistance with chronic hepatitis B. We assessed the long?term efficacy (median follow-up of 20.18 months) of ADV add-on LAM therapy in 89 LAM-resistant patients. Methods: 89 patients (29.2% cirrhotics, 76.4% hepatitis B e antigen positive) with LAM resistant patients who were not experienced ADV monotherapy were enrolled, retrospectively from August 2005 to October 2010. All the patients were treated with ADV add-on LAM therapy. Liver function test, hepatitis B virus (HBV) DNA and HBeAg/HBeAb were assessed every 3 months. ADV associated (rtA181T/V and rtN236T) mutations were looked for at intervals in all HBV DNA-positive serum samples, yearly Results: Cumulative ratio of undetectable HBV DNA level (<50 copies/mL or <8.6 IU/mL) at 6 months, 1 year, and 2 years were 15.7%/44.2%/45.4% for HBeAg positive group and 34.8%/39.1%/52.6% in HBeAg negative group. Seroconversion was observed 10.2%/19.7%/23.6% in 6 months, 1 year, and 2 years. Virologic breakthrough phenomenon was seen 1.1%. Conclusions: LAM and ADV combination therapy effectively suppresses HBV replication and prevents virologic and clinical breakthrough in LMV-resistant patients. And emergence of ADV-resistant mutants is rare, at least over a period of 24 months.
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국문요약
차례
그림 차례
표 차례
Ⅰ. 서론 1
Ⅱ. 연구대상 및 방법 3
A. 연구대상 3
B. 연구방법 3
C. 통계 4
Ⅲ. 결과 5
A. 대상 환자군의 치료 전 특성 5
B. 치료 반응 6
C. 바이러스 돌파 현상의 관찰 9
D. 유전자형 내성 빈도의 관찰 10
Ⅳ. 고찰 14
Ⅴ. 결론 17
참고문헌 18
ABSTRACT 22
